2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Chlorzoxazone-d3

Chlorzoxazone-d3 is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

For research use only. We do not sell to patients.

Chlorzoxazone-d<sub>3</sub> Chemical Structure

Chlorzoxazone-d3 Chemical Structure

CAS No. : 1185173-60-7

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1 mg USD 150 In-stock
5 mg USD 630 In-stock
10 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Chlorzoxazone-d3:

Chlorzoxazone-d3 Related Antibodies

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Description

Chlorzoxazone-d3 is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorzoxazone-d3 Related Antibodies
Molecular Weight

172.58

Formula

C7HD3ClNO2
CAS No.
Unlabeled Cas

95-25-0
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C1OC2=C([2H])C([2H])=C(Cl)C([2H])=C2N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (579.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7944 mL 28.9721 mL 57.9441 mL
5 mM 1.1589 mL 5.7944 mL 11.5888 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7944 mL 28.9721 mL 57.9441 mL 144.8604 mL
5 mM 1.1589 mL 5.7944 mL 11.5888 mL 28.9721 mL
10 mM 0.5794 mL 2.8972 mL 5.7944 mL 14.4860 mL
15 mM 0.3863 mL 1.9315 mL 3.8629 mL 9.6574 mL
20 mM 0.2897 mL 1.4486 mL 2.8972 mL 7.2430 mL
25 mM 0.2318 mL 1.1589 mL 2.3178 mL 5.7944 mL
30 mM 0.1931 mL 0.9657 mL 1.9315 mL 4.8287 mL
40 mM 0.1449 mL 0.7243 mL 1.4486 mL 3.6215 mL
50 mM 0.1159 mL 0.5794 mL 1.1589 mL 2.8972 mL
60 mM 0.0966 mL 0.4829 mL 0.9657 mL 2.4143 mL
80 mM 0.0724 mL 0.3622 mL 0.7243 mL 1.8108 mL
100 mM 0.0579 mL 0.2897 mL 0.5794 mL 1.4486 mL
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Chlorzoxazone-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorzoxazone-d31185173-60-7Cytochrome P450CYPsInhibitorinhibitorinhibit

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