2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Cetirizine-d4

Cetirizine-d4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

For research use only. We do not sell to patients.

Cetirizine-d<sub>4</sub> Chemical Structure

Cetirizine-d4 Chemical Structure

CAS No. : 1219803-84-5

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10 mg USD 1360 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cetirizine-d4:

Cetirizine-d4 Related Antibodies

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Description

Cetirizine-d4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

IC50 & Target

H1 Receptor

 

Molecular Weight

392.91

Formula

C21H21D4ClN2O3
CAS No.
Unlabeled CAS

83881-52-1
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC([2H])([2H])C([2H])([2H])N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (636.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5451 mL 12.7256 mL 25.4511 mL
5 mM 0.5090 mL 2.5451 mL 5.0902 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5451 mL 12.7256 mL 25.4511 mL 63.6278 mL
5 mM 0.5090 mL 2.5451 mL 5.0902 mL 12.7256 mL
10 mM 0.2545 mL 1.2726 mL 2.5451 mL 6.3628 mL
15 mM 0.1697 mL 0.8484 mL 1.6967 mL 4.2419 mL
20 mM 0.1273 mL 0.6363 mL 1.2726 mL 3.1814 mL
25 mM 0.1018 mL 0.5090 mL 1.0180 mL 2.5451 mL
30 mM 0.0848 mL 0.4242 mL 0.8484 mL 2.1209 mL
40 mM 0.0636 mL 0.3181 mL 0.6363 mL 1.5907 mL
50 mM 0.0509 mL 0.2545 mL 0.5090 mL 1.2726 mL
60 mM 0.0424 mL 0.2121 mL 0.4242 mL 1.0605 mL
80 mM 0.0318 mL 0.1591 mL 0.3181 mL 0.7953 mL
100 mM 0.0255 mL 0.1273 mL 0.2545 mL 0.6363 mL
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Cetirizine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cetirizine-d41219803-84-5Histamine ReceptorhistamineSARARIL-1βGM-CSFIL-8SeasonalallergicrhinitisInhibitorinhibitorinhibit

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