2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Ceftazidime pentahydrate

Ceftazidime pentahydrate  (Synonyms: GR20263 pentahydrate)

Cat. No.: HY-B0593A Purity: 98.84%
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Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.

For research use only. We do not sell to patients.

Ceftazidime pentahydrate Chemical Structure

Ceftazidime pentahydrate Chemical Structure

CAS No. : 78439-06-2

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Based on 20 publication(s) in Google Scholar

Other Forms of Ceftazidime pentahydrate:

Ceftazidime pentahydrate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases[1].

IC50 & Target

β-lactam

 

In Vitro

Ceftazidime (0-8 µg/mL approximately, 24 h) pentahydrate displays antibacterial and anti-biofilm activities against P. aeruginosa strains[2].
Ceftazidime (0-40 µg/mL approximately, 18-20 h) pentahydrate has inhibitory activities against S. maltophilia isolates[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ceftazidime pentahydrate Related Antibodies

Cell Viability Assay[2]

Cell Line: P. aeruginosa strains (PAO1, PA1, PA2)
Concentration: 0-8 µg/mL approximately
Incubation Time: 24 h
Result: Displayed antibacterial and anti-biofilm activities with MIC values of 2-4 µg/mL.
In Vivo

Ceftazidime (2 h infusion of injection, 2 000 mg, every 8 h for 24 h) pentahydrate moderately reduces bacterial density in a murine thigh infection model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine thigh infection model[4]
Dosage: 2000 mg
Administration: 2 h infusion of injection, every 8 h for 24 h.
Result: Reduced bacterial density against the isogenic NDM (New Delhi metallo-β-lactamase) strain.
Clinical Trial
Molecular Weight

636.65

Formula

C22H32N6O12S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC(C)(C(O)=O)C)=O)[C@@]3([H])SCC(C[N+]4=CC=CC=C4)=C(C([O-])=O)N13.[5H2O]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (157.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 31.25 mg/mL (49.09 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5707 mL 7.8536 mL 15.7072 mL
5 mM 0.3141 mL 1.5707 mL 3.1414 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (3.93 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (3.93 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.84%

COA (258 KB) HNMR (284 KB) RP-HPLC (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.5707 mL 7.8536 mL 15.7072 mL 39.2680 mL
5 mM 0.3141 mL 1.5707 mL 3.1414 mL 7.8536 mL
10 mM 0.1571 mL 0.7854 mL 1.5707 mL 3.9268 mL
15 mM 0.1047 mL 0.5236 mL 1.0471 mL 2.6179 mL
20 mM 0.0785 mL 0.3927 mL 0.7854 mL 1.9634 mL
25 mM 0.0628 mL 0.3141 mL 0.6283 mL 1.5707 mL
30 mM 0.0524 mL 0.2618 mL 0.5236 mL 1.3089 mL
40 mM 0.0393 mL 0.1963 mL 0.3927 mL 0.9817 mL
DMSO 50 mM 0.0314 mL 0.1571 mL 0.3141 mL 0.7854 mL
60 mM 0.0262 mL 0.1309 mL 0.2618 mL 0.6545 mL
80 mM 0.0196 mL 0.0982 mL 0.1963 mL 0.4909 mL
100 mM 0.0157 mL 0.0785 mL 0.1571 mL 0.3927 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ceftazidime pentahydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceftazidime78439-06-2GR20263GR 20263GR-20263Beta-lactamaseBacterialAntibioticβ-lactamaseBiofilmGramthigh infectionlactamaseinfectionInhibitorinhibitorinhibit

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