2. PROTAC Neuronal Signaling
  3. PROTACs Tau Protein
  4. C004019

C004019 is a small-molecule PROTAC. C004019 simultaneously recruites tau and E3-ligase (Vhl) and thus selectively enhances ubiquitination and proteolysis of tau proteins. C004019 can be used for Alzheimer disease (AD) research.

For research use only. We do not sell to patients.

C004019 Chemical Structure

C004019 Chemical Structure

CAS No. : 2417159-57-8

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5 mg USD 780 In-stock
10 mg USD 1140 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

C004019 is a small-molecule PROTAC. C004019 simultaneously recruites tau and E3-ligase (Vhl) and thus selectively enhances ubiquitination and proteolysis of tau proteins. C004019 can be used for Alzheimer disease (AD) research[1].

IC50 & Target

VHL

 

Molecular Weight

1035.29

Formula

C49H70N12O9S2
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCNC(CN(C4=NC(N5CCN(CCC5)C(C)=O)=NC(NCCC6=CC=CS6)=N4)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (48.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9659 mL 4.8296 mL 9.6591 mL
5 mM 0.1932 mL 0.9659 mL 1.9318 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9659 mL 4.8296 mL 9.6591 mL 24.1478 mL
5 mM 0.1932 mL 0.9659 mL 1.9318 mL 4.8296 mL
10 mM 0.0966 mL 0.4830 mL 0.9659 mL 2.4148 mL
15 mM 0.0644 mL 0.3220 mL 0.6439 mL 1.6099 mL
20 mM 0.0483 mL 0.2415 mL 0.4830 mL 1.2074 mL
25 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9659 mL
30 mM 0.0322 mL 0.1610 mL 0.3220 mL 0.8049 mL
40 mM 0.0241 mL 0.1207 mL 0.2415 mL 0.6037 mL
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C004019 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C0040192417159-57-8C 004019C-004019PROTACsTau ProteinHEK293SH-SY5YInhibitorinhibitorinhibit

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