2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-18

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo.

For research use only. We do not sell to patients.

BTK-IN-18 Chemical Structure

BTK-IN-18 Chemical Structure

CAS No. : 1374239-71-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

BTK-IN-18 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo[1].

In Vivo

BTK-IN-18 (compound 41; 10, 25, 45 mg/kg; IP; single dose) causes robust dose-dependent inhibition of both CD69 and CD86[1].
BTK-IN-18 (iv; 1 mg/kg) has a T1/2 of 5.3 hours, a CL of 19 mL/min/kg, and a Vss of 1.3 L/kg for rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 10, 25, 45 mg/kg
Administration: IP; single dose
Result: Caused robust dose-dependent inhibition of both CD69 and CD86 (74.8 %, 50.3 %, and 21.5 % respectively).
Animal Model:
Dosage:
Administration:
Result: Pharmacokinetic Parameters of BTK-IN-18 in rats[1].
IV (1 mg/kg) PO (5 mg/kg)
Tmax (h) 1.6
Cmax (h∗mg/mL) 321
AUCinfi (h∗mg/mL) 1013 1421
t1/2 (ng/mL) 5.3
CL (mL/min/kg) 19
Vss (L/kg) 1.3
F (%) 23%
Molecular Weight

433.33

Formula

C20H22Cl2N6O
CAS No.
SMILES

C[C@@H]1[C@@H](CCCN1C(CNC2=CC(Cl)=CC(Cl)=C2)=O)NC3=C4C=CNC4=NC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BTK-IN-18 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-181374239-71-0BtkBruton tyrosine kinaseBTKCD69CD86Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BTK-IN-18
Cat. No.:
HY-152201
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.