2. Others GPCR/G Protein Neuronal Signaling
  3. Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor
  4. Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d8  (Synonyms: DM-3411 d8)

Cat. No.: HY-133152S Purity: 98.72%
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Brexpiprazole S-oxide-d8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

For research use only. We do not sell to patients.

Brexpiprazole S-oxide-d<sub>8</sub> Chemical Structure

Brexpiprazole S-oxide-d8 Chemical Structure

CAS No. : 2748605-29-8

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1 mg USD 530 In-stock
5 mg USD 1480 In-stock
10 mg USD 2500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Brexpiprazole S-oxide-d8:

Brexpiprazole S-oxide-d8 Related Antibodies

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Description

Brexpiprazole S-oxide-d8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

IC50 & Target[2]

5-HT1A Receptor

0.12 nM (Ki)

5-HT2A Receptor

0.47 nM (Ki)

D2 Receptor

0.3 nM (Ki)

Molecular Weight

457.61

Formula

C25H19D8N3O3S
CAS No.
Unlabeled CAS

1191900-51-2
Appearance

Solid

Color

White to off-white

SMILES

O=S1C=CC2=C(N3C([2H])([2H])C([2H])([2H])N(CCCCOC4=CC=C(C=CC(N5)=O)C5=C4)C([2H])([2H])C3([2H])[2H])C=CC=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (54.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1853 mL 10.9263 mL 21.8527 mL
5 mM 0.4371 mL 2.1853 mL 4.3705 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1853 mL 10.9263 mL 21.8527 mL 54.6317 mL
5 mM 0.4371 mL 2.1853 mL 4.3705 mL 10.9263 mL
10 mM 0.2185 mL 1.0926 mL 2.1853 mL 5.4632 mL
15 mM 0.1457 mL 0.7284 mL 1.4568 mL 3.6421 mL
20 mM 0.1093 mL 0.5463 mL 1.0926 mL 2.7316 mL
25 mM 0.0874 mL 0.4371 mL 0.8741 mL 2.1853 mL
30 mM 0.0728 mL 0.3642 mL 0.7284 mL 1.8211 mL
40 mM 0.0546 mL 0.2732 mL 0.5463 mL 1.3658 mL
50 mM 0.0437 mL 0.2185 mL 0.4371 mL 1.0926 mL
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Brexpiprazole S-oxide-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brexpiprazole S-oxide-d82748605-29-8DM-3411 d8Isotope-Labeled Compounds5-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorMetabolitedeuteriumlabeledBrexpiprazoleCYP3A45-HT1A5-HT2AInhibitorinhibitorinhibit

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