2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG3-C3-NH2

Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG3-C3-NH2 Chemical Structure

Biotin-PEG3-C3-NH2 Chemical Structure

CAS No. : 183896-00-6

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100 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Biotin-PEG3-C3-NH2:

Biotin-PEG3-C3-NH2 Related Antibodies

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  • Biological Activity

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Description

Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
PROTAC can significantly attenuate tumor progression in tumor xenografts[1].
Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG3-C3-NH2 Related Antibodies
Molecular Weight

446.60

Formula

C20H38N4O5S
CAS No.
Unlabeled CAS

Appearance

Oil

Color

Colorless to light yellow

SMILES

NCCCOCCOCCOCCCNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Methanol : ≥ 175 mg/mL (391.85 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2391 mL 11.1957 mL 22.3914 mL
5 mM 0.4478 mL 2.2391 mL 4.4783 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.2391 mL 11.1957 mL 22.3914 mL 55.9785 mL
5 mM 0.4478 mL 2.2391 mL 4.4783 mL 11.1957 mL
10 mM 0.2239 mL 1.1196 mL 2.2391 mL 5.5979 mL
15 mM 0.1493 mL 0.7464 mL 1.4928 mL 3.7319 mL
20 mM 0.1120 mL 0.5598 mL 1.1196 mL 2.7989 mL
25 mM 0.0896 mL 0.4478 mL 0.8957 mL 2.2391 mL
30 mM 0.0746 mL 0.3732 mL 0.7464 mL 1.8660 mL
40 mM 0.0560 mL 0.2799 mL 0.5598 mL 1.3995 mL
50 mM 0.0448 mL 0.2239 mL 0.4478 mL 1.1196 mL
60 mM 0.0373 mL 0.1866 mL 0.3732 mL 0.9330 mL
80 mM 0.0280 mL 0.1399 mL 0.2799 mL 0.6997 mL
100 mM 0.0224 mL 0.1120 mL 0.2239 mL 0.5598 mL
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Biotin-PEG3-C3-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG3-C3-NH2183896-00-6PROTAC LinkersbiotinPEGPROteolysis-TArgeting Chimerasubiquitin-proteasomeE3 ubiquitin ligaseanti-tumorInhibitorinhibitorinhibit

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