Tubulin polymerization-promoting protein family member 2

Definition:

Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity.

References:

[1]. Feng Zhu, et al. Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice. J Cell Mol Med. 2019 Apr;23(4):2583-2594. [Content Brief]

[2]. Orsolya Vincze, et al. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry. 2006 Nov 21;45(46):13818-26. [Content Brief]

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