tRNA wybutosine-synthesizing protein 5

Definition:

tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.

References:

[1]. Akiko Noma, et al. Expanding role of the jumonji C domain as an RNA hydroxylase. J Biol Chem. 2010 Nov 5;285(45):34503-7. [Content Brief]

[2]. Megumi Kato, et al. Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. Nucleic Acids Res. 2011 Mar;39(4):1576-85. [Content Brief]

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