Trinucleotide repeat-containing gene 6B protein

Definition:

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

References:

[1]. Gunter Meister, et al. Identification of novel argonaute-associated proteins. Curr Biol. 2005 Dec 6;15(23):2149-55. [Content Brief]

[2]. Felix Räsch, et al. 4E-T-bound mRNAs are stored in a silenced and deadenylated form. Genes Dev. 2020 Jun 1;34(11-12):847-860. [Content Brief]

[3]. Joerg E Braun, et al. GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell. 2011 Oct 7;44(1):120-33. [Content Brief]

[4]. Lasse Weinmann, et al. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell. 2009 Feb 6;136(3):496-507. [Content Brief]

[5]. Jakob T Zipprich, et al. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA. 2009 May;15(5):781-93. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.