Trehalase deficiency

Definition:

Trehalase deficiency is a disorder characterized by abdominal pain, distention, and flatulence after trehalose ingestion. Trehalose is a disaccharide found in mushrooms, algae, and insect haemolymph. Intestinal trehalase (encoded by TREH) is a beta-galactosidase which catalyses the hydrolysis of trehalose to two glucose molecules for absorption.

References:

[1]. Danish Saleheen, et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 Apr 12;544(7649):235-239. [Content Brief]

[2]. E Gudmand-Høyer, et al. Trehalase deficiency in Greenland. Scand J Gastroenterol. 1988 Sep;23(7):775-8. [Content Brief]

[3]. I A Murray, et al. Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease. Br J Nutr. 2000 Mar;83(3):241-5. [Content Brief]

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