Transcription termination factor 2

Definition:

DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

References:

[1]. M Liu, et al. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. J Biol Chem. 1998 Oct 2;273(40):25541-4. [Content Brief]

[2]. Deana Leonard, et al. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. Biochem Biophys Res Commun. 2003 Sep 5;308(4):793-801. [Content Brief]

[3]. Yan Jiang, et al. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. Mol Cell. 2004 May 7;14(3):375-85. [Content Brief]

[4]. R Hara, et al. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. J Biol Chem. 1999 Aug 27;274(35):24779-86. [Content Brief]

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