Transcription factor Spi-B

Definition:

Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.

References:

[1]. D Ray, et al. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol. 1992 Oct;12(10):4297-304. [Content Brief]

[2]. Remko Schotte, et al. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med. 2004 Dec 6;200(11):1503-9. [Content Brief]

[3]. Remko Schotte, et al. The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. Blood. 2003 Feb 1;101(3):1015-23. [Content Brief]

[4]. S Rao, et al. SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. J Biol Chem. 1999 Apr 16;274(16):11115-24. [Content Brief]

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