Transcription factor IIIB 50 kDa subunit

Definition:

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.

References:

[1]. M Teichmann, et al. A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14200-5. [Content Brief]

[2]. Jerome Gouge, et al. Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell. 2015 Dec 3;163(6):1375-87. [Content Brief]

[3]. L Schramm, et al. Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. Genes Dev. 2000 Oct 15;14(20):2650-63. [Content Brief]

[4]. P Cabart, et al. BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein. J Biol Chem. 2001 Nov 16;276(46):43056-64. [Content Brief]

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