Transcription factor EC

Definition:

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.

References:

[1]. K Yasumoto, et al. Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator. Biochim Biophys Acta. 1997 Jul 17;1353(1):23-31. [Content Brief]

[2]. M C Chung, et al. TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells. Biochemistry. 2001 Jul 31;40(30):8887-97. [Content Brief]

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