Transcription factor 7-like 2

Definition:

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

References:

[1]. T C He, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998 Sep 4;281(5382):1509-12. [Content Brief]

[2]. Hideki Yamamoto, et al. Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. EMBO J. 2003 May 1;22(9):2047-59. [Content Brief]

[3]. Yu Yu, et al. Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling. EMBO Rep. 2012 Aug;13(8):750-8. [Content Brief]

[4]. Marc van de Wetering, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 2002 Oct 18;111(2):241-50. [Content Brief]

[5]. Chun-Fu Hong, et al. MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation. J Biol Chem. 2009 Jul 17;284(29):19613-22. [Content Brief]

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