Transcription elongation factor A protein 2

Definition:

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

References:

[1]. Robert Sijbrandi, et al. RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage. Nucleic Acids Res. 2002 Jun 1;30(11):2290-8. [Content Brief]

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