Torsin-1B

Definition:

May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues.

References:

[1]. April E Rose, et al. Arresting a Torsin ATPase reshapes the endoplasmic reticulum. J Biol Chem. 2014 Jan 3;289(1):552-64. [Content Brief]

[2]. Chenguang Zhao, et al. Regulation of Torsin ATPases by LAP1 and LULL1. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1545-54. [Content Brief]

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