TNF related apoptosis-inducing ligand receptor 1 (TRAIL-R1)

Definition:

Tumor necrosis factor-related apoptosis-inducing ligand 1 (TRAIL-R1) is a potent endogenous activator of the cell death pathway and functions by activating the cell surface death receptors 4 and 5 (DR4 and DR5).

References:

[1]. Chinnaiyan AM, et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1754-9. [Content Brief]

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