Thymidylate kinase

Definition:

Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).

References:

[1]. Jo M Vanoevelen, et al. DTYMK is essential for genome integrity and neuronal survival. Acta Neuropathol. 2022 Feb;143(2):245-262. [Content Brief]

[2]. J Y Su, et al. Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast. Nucleic Acids Res. 1991 Feb 25;19(4):823-7. [Content Brief]

[3]. S H Huang, et al. Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. DNA Cell Biol. 1994 May;13(5):461-71. [Content Brief]

[4]. Nils Ostermann, et al. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. Biochemistry. 2003 Mar 11;42(9):2568-77. [Content Brief]

[5]. L S Lee, et al. Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia. J Biol Chem. 1977 Aug 25;252(16):5686-91. [Content Brief]

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