Threonylcarbamoyl-AMP synthase

Definition:

Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs. May regulate the activity of some transporters (By similarity).

References:

[1]. Huan Lin, et al. CO2-sensitive tRNA modification associated with human mitochondrial disease. Nat Commun. 2018 May 14;9(1):1875. [Content Brief]

[2]. Julia Schmidt, et al. Biallelic variants in YRDC cause a developmental disorder with progeroid features. Hum Genet. 2021 Dec;140(12):1679-1693. [Content Brief]

[3]. Christelle Arrondel, et al. Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. Nat Commun. 2019 Sep 3;10(1):3967. [Content Brief]

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