TBC1 domain family member 20

Definition:

GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. Involved in maintaining endoplasmic reticulum structure.

References:

[1]. Andreas Gerondopoulos, et al. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014 Jun 9;205(5):707-20. [Content Brief]

[2]. Konstantin Gavriljuk, et al. Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21348-53. [Content Brief]

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