TBC1 domain family member 17

Definition:

Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR). Involved in regulation of autophagy.

References:

[1]. Vipul Vaibhava, et al. Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J Cell Sci. 2012 Nov 1;125(Pt 21):5026-39. [Content Brief]

[2]. Madhavi Latha Somaraju Chalasani, et al. E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy. PLoS One. 2014 Apr 21;9(4):e95758. [Content Brief]

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