Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Definition:

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

References:

[1]. Sabine Grønborg, et al. Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling. JIMD Rep. 2017;33:69-77. [Content Brief]

[2]. Anna Ardissone, et al. Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance. Mol Genet Metab Rep. 2015 Dec;5:51-54. [Content Brief]

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