Serpin B6

Definition:

May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.

References:

[1]. Fiona L Scott, et al. SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem. 2007 Oct;142(4):435-42. [Content Brief]

[2]. P Coughlin, et al. Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9417-21. [Content Brief]

[3]. Asli Sirmaci, et al. A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. Am J Hum Genet. 2010 May 14;86(5):797-804. [Content Brief]

[4]. F L Scott, et al. The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G. Blood. 1999 Mar 15;93(6):2089-97. [Content Brief]

[5]. K A Morgenstern, et al. Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases. Biochemistry. 1994 Mar 22;33(11):3432-41. [Content Brief]

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