Interleukin-3 receptor subunit alpha

Definition:

Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity).

References:

[1]. Sophie E Broughton, et al. A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nat Commun. 2018 Jan 26;9(1):386. [Content Brief]

[2]. S Huang, et al. Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues. Stem Cells. 1999;17(5):265-72. [Content Brief]

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