Cyclin-Y

Definition:

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

References:

[1]. Gary Davidson, et al. Cell cycle control of wnt receptor activation. Dev Cell. 2009 Dec;17(6):788-99. [Content Brief]

[2]. Mei Jiang, et al. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Lett. 2009 Jul 7;583(13):2171-8. [Content Brief]

[3]. Xuanyang Li, et al. Identification and characterization of cyclin X which activates transcriptional activities of c-Myc. Mol Biol Rep. 2009 Jan;36(1):97-103. [Content Brief]

[4]. Petra Mikolcevic, et al. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol. 2012 Feb;32(4):868-79. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.