Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

Definition:

Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).

References:

[1]. Siddhesh Aras, et al. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Nucleic Acids Res. 2013 Feb 1;41(4):2255-66. [Content Brief]

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