CD320 antigen

Definition:

Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.

References:

[1]. L Li, et al. Identification of a human follicular dendritic cell molecule that stimulates germinal center B cell growth. J Exp Med. 2000 Mar 20;191(6):1077-84. [Content Brief]

[2]. Edward V Quadros, et al. The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin. Blood. 2009 Jan 1;113(1):186-92. [Content Brief]

[3]. X Zhang, et al. The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation. J Immunol. 2001 Jul 1;167(1):49-56. [Content Brief]

[4]. Edward V Quadros, et al. Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12). Hum Mutat. 2010 Aug;31(8):924-9. [Content Brief]

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