Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

Definition:

Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively. Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells.

References:

[1]. K Sasaki, et al. Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). J Biol Chem. 1994 Jun 3;269(22):15950-6. [Content Brief]

[2]. Yihua Gu, et al. Identification and analysis of novel functional sites in human GD3-synthase. Biochem Biophys Res Commun. 2008 May 23;370(1):67-71. [Content Brief]

[3]. J Nakayama, et al. Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme. J Biol Chem. 1996 Feb 16;271(7):3684-91. [Content Brief]

[4]. Agata Steenackers, et al. Accumulation of unusual gangliosides G(Q3) and G(P3) in breast cancer cells expressing the G(D3) synthase. Molecules. 2012 Aug 10;17(8):9559-72. [Content Brief]

[5]. K Nara, et al. Acceptor substrate specificity of a cloned GD3 synthase that catalyzes the biosynthesis of both GD3 and GD1c/GT1a/GQ1b. Eur J Biochem. 1996 Jun 15;238(3):647-52. [Content Brief]

[6]. M Haraguchi, et al. Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10455-9. [Content Brief]

[7]. K Nara, et al. Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7952-6. [Content Brief]

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