Benzocaine-(ethyl-d₅)

Name: Benzocaine-(ethyl-d 5 )
Brand: MedChemExpress
SKU: HY-Y0258S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y0258S1 Purity: 99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

For research use only. We do not sell to patients.

Benzocaine-(ethyl-d<sub>5</sub>) Chemical Structure

Benzocaine-(ethyl-d₅) Chemical Structure

CAS No. : 1219803-76-5

Size	Price	Stock	Quantity
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Benzocaine-(ethyl-d₅):

Benzocaine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

170.22

Formula

C₉H₆D₅NO₂

CAS No.

1219803-76-5

Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C([2H])([2H])OC(C1=CC=C(C=C1)N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (587.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2 mg/mL (11.75 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8748 mL	29.3738 mL	58.7475 mL
5 mM	1.1750 mL	5.8748 mL	11.7495 mL
10 mM	0.5875 mL	2.9374 mL	5.8748 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302. [Content Brief]

[3]. Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6. [Content Brief]

[4]. Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O / DMSO	1 mM	5.8748 mL	29.3738 mL	58.7475 mL	146.8688 mL
	5 mM	1.1750 mL	5.8748 mL	11.7495 mL	29.3738 mL
	10 mM	0.5875 mL	2.9374 mL	5.8748 mL	14.6869 mL
DMSO	15 mM	0.3917 mL	1.9583 mL	3.9165 mL	9.7913 mL
	20 mM	0.2937 mL	1.4687 mL	2.9374 mL	7.3434 mL
	25 mM	0.2350 mL	1.1750 mL	2.3499 mL	5.8748 mL
	30 mM	0.1958 mL	0.9791 mL	1.9583 mL	4.8956 mL
	40 mM	0.1469 mL	0.7343 mL	1.4687 mL	3.6717 mL
	50 mM	0.1175 mL	0.5875 mL	1.1750 mL	2.9374 mL
	60 mM	0.0979 mL	0.4896 mL	0.9791 mL	2.4478 mL
	80 mM	0.0734 mL	0.3672 mL	0.7343 mL	1.8359 mL
	100 mM	0.0587 mL	0.2937 mL	0.5875 mL	1.4687 mL