2. Others Membrane Transporter/Ion Channel Neuronal Signaling
  3. Isotope-Labeled Compounds nAChR
  4. Asoxime-d4 dichloride

Asoxime-d4 dichloride  (Synonyms: HI-6-d4)

Cat. No.: HY-106901AS Purity: ≥96.0%
COA Handling Instructions

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Asoxime-d4 (dichloride) is the deuterium labeled Asoxime dichloride. Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].

For research use only. We do not sell to patients.

Asoxime-d<sub>4</sub> dichloride Chemical Structure

Asoxime-d4 dichloride Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Asoxime-d4 dichloride:

Asoxime-d4 dichloride Related Antibodies

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Description

Asoxime-d4 (dichloride) is the deuterium labeled Asoxime dichloride. Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Asoxime-d4 dichloride Related Antibodies
Molecular Weight

363.23

Formula

C14H12D4Cl2N4O3
Unlabeled CAS

34433-31-3
Appearance

Solid

Color

White to off-white

SMILES

O/N=C/C1=CC=CC=[N+]1COC[N+]2=C([2H])C([2H])=C(C(N)=O)C([2H])=C2[2H].[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

PBS (pH 7.2) : ≥ 10 mg/mL (27.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7531 mL 13.7654 mL 27.5308 mL
5 mM 0.5506 mL 2.7531 mL 5.5062 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥96.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) 1 mM 2.7531 mL 13.7654 mL 27.5308 mL 68.8269 mL
5 mM 0.5506 mL 2.7531 mL 5.5062 mL 13.7654 mL
10 mM 0.2753 mL 1.3765 mL 2.7531 mL 6.8827 mL
15 mM 0.1835 mL 0.9177 mL 1.8354 mL 4.5885 mL
20 mM 0.1377 mL 0.6883 mL 1.3765 mL 3.4413 mL
25 mM 0.1101 mL 0.5506 mL 1.1012 mL 2.7531 mL
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Asoxime-d4 dichloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asoxime-d4 dichlorideHI-6-d4Isotope-Labeled CompoundsnAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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