Aripiprazole (1,1,2,2,3,3,4,4-d₈)

Name: Aripiprazole (1,1,2,2,3,3,4,4-d 8 )
Brand: MedChemExpress
SKU: HY-14546S1
Rating: 5.0 (8 reviews)

Cat. No.: HY-14546S1: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Aripiprazole (1,1,2,2,3,3,4,4-d₈) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2].

For research use only. We do not sell to patients.

Aripiprazole (1,1,2,2,3,3,4,4-d<sub>8</sub>) Chemical Structure

Aripiprazole (1,1,2,2,3,3,4,4-d₈) Chemical Structure

CAS No. : 1089115-04-7

Size	Price	Stock	Quantity
1 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 8 publication(s) in Google Scholar

Other Forms of Aripiprazole (1,1,2,2,3,3,4,4-d₈):

Aripiprazole In-stock

8 Publications Citing Use of MCE Aripiprazole (1,1,2,2,3,3,4,4-d₈)

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Aripiprazole (1,1,2,2,3,3,4,4-d₈) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

456.43

Formula

C₂₃H₁₉D₈Cl₂N₃O₂

CAS No.

1089115-04-7

Unlabeled CAS

129722-12-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C=CC(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 30 mg/mL (65.73 mM)

DMSO : ≥ 25 mg/mL (54.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 1 mg/mL (2.19 mM)

DMF:PBS (pH 7.2) (1:1) : ≥ 0.12 mg/mL (0.26 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1909 mL	10.9546 mL	21.9092 mL
5 mM	0.4382 mL	2.1909 mL	4.3818 mL
10 mM	0.2191 mL	1.0955 mL	2.1909 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20. [Content Brief]

[3]. Burris KD, Molski TF, Xu C et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9. [Content Brief]

[4]. Swainston Harrison T, Perry CM. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36. [Content Brief]

[5]. Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T. Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T. Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier. Biopharm Drug Dispos. 2012 Jul 27. doi: 10.1002/bdd.1801. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO / DMF	1 mM	2.1909 mL	10.9546 mL	21.9092 mL	54.7729 mL
DMSO / DMF	5 mM	0.4382 mL	2.1909 mL	4.3818 mL	10.9546 mL
	10 mM	0.2191 mL	1.0955 mL	2.1909 mL	5.4773 mL
	15 mM	0.1461 mL	0.7303 mL	1.4606 mL	3.6515 mL
	20 mM	0.1095 mL	0.5477 mL	1.0955 mL	2.7386 mL
	25 mM	0.0876 mL	0.4382 mL	0.8764 mL	2.1909 mL
	30 mM	0.0730 mL	0.3652 mL	0.7303 mL	1.8258 mL
	40 mM	0.0548 mL	0.2739 mL	0.5477 mL	1.3693 mL
	50 mM	0.0438 mL	0.2191 mL	0.4382 mL	1.0955 mL
DMF	60 mM	0.0365 mL	0.1826 mL	0.3652 mL	0.9129 mL