2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Melatonin Receptor 5-HT Receptor Endogenous Metabolite
  4. Agomelatin-d3

Agomelatin-d3  (Synonyms: S-20098-d3)

Cat. No.: HY-17038S2 Purity: ≥98.0%
COA Handling Instructions

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Agomelatin-d3 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

For research use only. We do not sell to patients.

Agomelatin-d<sub>3</sub> Chemical Structure

Agomelatin-d3 Chemical Structure

CAS No. : 1079389-38-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Agomelatin-d3:

Agomelatin-d3 Related Antibodies

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Description

Agomelatin-d3 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

IC50 & Target

MT2

 

MT1

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Agomelatin-d3 Related Antibodies
Molecular Weight

246.32

Formula

C15H14D3NO2
CAS No.
Unlabeled Cas

138112-76-2
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(NCCC1=CC=CC2=C1C=C(OC)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (405.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0598 mL 20.2988 mL 40.5976 mL
5 mM 0.8120 mL 4.0598 mL 8.1195 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0598 mL 20.2988 mL 40.5976 mL 101.4940 mL
5 mM 0.8120 mL 4.0598 mL 8.1195 mL 20.2988 mL
10 mM 0.4060 mL 2.0299 mL 4.0598 mL 10.1494 mL
15 mM 0.2707 mL 1.3533 mL 2.7065 mL 6.7663 mL
20 mM 0.2030 mL 1.0149 mL 2.0299 mL 5.0747 mL
25 mM 0.1624 mL 0.8120 mL 1.6239 mL 4.0598 mL
30 mM 0.1353 mL 0.6766 mL 1.3533 mL 3.3831 mL
40 mM 0.1015 mL 0.5075 mL 1.0149 mL 2.5373 mL
50 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0299 mL
60 mM 0.0677 mL 0.3383 mL 0.6766 mL 1.6916 mL
80 mM 0.0507 mL 0.2537 mL 0.5075 mL 1.2687 mL
100 mM 0.0406 mL 0.2030 mL 0.4060 mL 1.0149 mL
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Agomelatin-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Agomelatin-d31079389-38-0S-20098-d3Melatonin Receptor5-HT ReceptorEndogenous MetaboliteSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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