Urotensin II (114-124), human 

Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

GPR14^[1]

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC₅₀=0:62±0.17 nM, n=6)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1388.57

C₆₄H₈₅N₁₃O₁₈S₂

251293-28-4

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)

ETPDCFWKYCV (Disulfide bridge: Cys5-Cys7)

O=C([C@@H](NC([C@@](CSSC[C@@H](C(N[C@H](C(O)=O)C(C)C)=O)NC([C@H](CC1=CC=C(O)C=C1)NC([C@@](CCCCN)([H])NC2=O)=O)=O)([H])NC([C@H](CC(O)=O)NC([C@H]3N(CCC3)C([C@H]([C@H](O)C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)N[C@H]2CC5=CNC6=C5C=CC=C6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.  [Content Brief]