1. Signaling Pathways
  2. Anti-infection
  3. CMV

CMV

Cytomegalovirus

Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the ubiquitous family of herpesviruses. Cytomegaloviruses escape immunological clearance and persist throughout life in the infected host. Yet, the stability of the balance of this virus-host interaction is dependent upon the state of the cellular immune response, and usually requires the function of specific CD8 T lymphocytes.

Human cytomegalovirus is a member of the viral family known as herpesviruses, Herpesviridae, or human herpesvirus-5 (HHV-5). Human cytomegalovirus infections commonly are associated with the salivary glands. CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer.

CMV Related Products (50):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114005
    SB-734117
    Inhibitor
    SB-734117 is a human cytomegalovirus (HCMV) replication inhibitor that prevents CREB and histone H3 post-translational modifications.
    SB-734117
  • HY-160917
    BAY-43-9695
    Inhibitor
    BAY-43-9695 is a nonnucleosidic with activity against human cytomegalovirus (hCMV) with IC50 of 0.95 and 1.1 μM, using the FACS and PRA methodes. BAY-43-9695 inhibits the HCMV replication with and without presence of serum proteins, with IC50 of 0.53 and 8.42 μM. BAY-43-9695 is the metabolite of Tomeglovir (BAY38-4766) (HY-108261).
    BAY-43-9695
  • HY-A0032S
    Valganciclovir-d5 TFA
    Valganciclovir-d5 (TFA) is the deuterium labeled Valganciclovir TFA[1]. Valganciclovir, the L-valyl ester of ganciclovir, is actually a proagent for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections[2][3][4].
    Valganciclovir-d<sub>5</sub> TFA
  • HY-A0032AR
    Valganciclovir hydrochloride (Standard)
    Inhibitor
    Valganciclovir (hydrochloride) (Standard) is the analytical standard of Valganciclovir (hydrochloride). This product is intended for research and analytical applications. Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus.
    Valganciclovir hydrochloride (Standard)
  • HY-41343
    Triacetyl-ganciclovir
    Inhibitor
    Triacetyl-ganciclovir is a Ganciclovir derivative. Ganciclovir is an orally active antiviral agent with activity against cytomegalovirus (CMV).
    Triacetyl-ganciclovir
  • HY-128370
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate
    Inhibitor
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication.
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate
  • HY-13578R
    Brivudine (Standard)
    Inhibitor
    Brivudine (Standard) is the analytical standard of Brivudine. This product is intended for research and analytical applications. Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
    Brivudine (Standard)
  • HY-146270
    pUL89 Endonuclease-IN-1
    Inhibitor
    pUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 value of 0.88 μM and has antiviral activitiy.
    pUL89 Endonuclease-IN-1
  • HY-A0032
    Valganciclovir
    Inhibitor
    Valganciclovir, the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir.
    Valganciclovir
  • HY-17438A
    Cidofovir dihydrate
    Inhibitor
    Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities.
    Cidofovir dihydrate