PNU-282987 S enantiomer free base

Cat. No.: HY-12560D Purity: 99.58%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist.

For research use only. We do not sell to patients.

PNU-282987 S enantiomer free base Chemical Structure

CAS No. : 737727-12-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 612	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 612	In-stock	Estimated Time of Arrival: December 31
Solid
2 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 840	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of PNU-282987 S enantiomer free base:

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Biological Activity
Purity & Documentation
References
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Description

PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist.

Molecular Weight

264.75

Formula

C₁₄H₁₇ClN₂O

CAS No.

737727-12-7

Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(Cl)C=C1)N[C@H]2C3CCN(CC3)C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (377.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7771 mL	18.8857 mL	37.7715 mL
5 mM	0.7554 mL	3.7771 mL	7.5543 mL
10 mM	0.3777 mL	1.8886 mL	3.7771 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (248 KB) LCMS (120 KB)

Handling Instructions (2659 KB)

References

[1]. Bodnar AL, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7771 mL	18.8857 mL	37.7715 mL	94.4287 mL
	5 mM	0.7554 mL	3.7771 mL	7.5543 mL	18.8857 mL
	10 mM	0.3777 mL	1.8886 mL	3.7771 mL	9.4429 mL
	15 mM	0.2518 mL	1.2590 mL	2.5181 mL	6.2952 mL
	20 mM	0.1889 mL	0.9443 mL	1.8886 mL	4.7214 mL
	25 mM	0.1511 mL	0.7554 mL	1.5109 mL	3.7771 mL
	30 mM	0.1259 mL	0.6295 mL	1.2590 mL	3.1476 mL
	40 mM	0.0944 mL	0.4721 mL	0.9443 mL	2.3607 mL
	50 mM	0.0755 mL	0.3777 mL	0.7554 mL	1.8886 mL
	60 mM	0.0630 mL	0.3148 mL	0.6295 mL	1.5738 mL
	80 mM	0.0472 mL	0.2361 mL	0.4721 mL	1.1804 mL
	100 mM	0.0378 mL	0.1889 mL	0.3777 mL	0.9443 mL