KKI-5 

KKI-5 is a specific inhibitor of tissue kallikrein. KKI-5 can attenuate breast cancer cell invasion^[1].

Kallikrein Inhibitor

The KKI-5 Peptide corresponds to aa386-391 of bovine kininogen-1 that encompasses the aa388-389 kallikrein proteolytic site. The synthetic KKI-5 can attenuate breast cancer cell invasion, therefore it is investigated for its role in invasion and metastasis of cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

773.88

C₃₅H₅₅N₁₁O₉

97145-43-2

Ac-Pro-Phe-Arg-Ser-Val-Gln-NH2

Ac-PFRSVQ-NH2

NC(CC[C@@H](C(N)=O)NC([C@H](C(C)C)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)NC([C@H]2N(CCC2)C(C)=O)=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Deshpande MS, et al. Mapping the binding site of tissue kallikrein: preparation and testing of all possible substrate analog inhibitors homologous with the sequence of kininogen between Ser386 and Gln392. J Med Chem. 1992 Aug 21;35(17):3094-102.  [Content Brief]