7ß-Hydroxycholesterol-d₇

Cat. No.: HY-113341S: FAQs
Data Sheet SDS COA Handling Instructions

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7ß-Hydroxycholesterol-d₇ is the deuterium labeled 7α-Hydroxycholesterol. 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death[1][2].

For research use only. We do not sell to patients.

7ß-Hydroxycholesterol-d<sub>7</sub> Chemical Structure

7ß-Hydroxycholesterol-d₇ Chemical Structure

CAS No. : 349553-97-5

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1 mg	USD 350	Ask For Quote & Lead Time

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Other Forms of 7ß-Hydroxycholesterol-d₇:

7β-Hydroxycholesterol In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

409.70

Formula

C₂₇H₃₉D₇O₂

CAS No.

349553-97-5

Unlabeled Cas

566-27-8

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@@H]3O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 20 mg/mL (48.82 mM)

DMF : ≥ 2 mg/mL (4.88 mM)

DMSO : ≥ 0.1 mg/mL (0.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4408 mL	12.2041 mL	24.4081 mL
5 mM	0.4882 mL	2.4408 mL	4.8816 mL
10 mM	0.2441 mL	1.2204 mL	2.4408 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / Ethanol	1 mM	2.4408 mL	12.2041 mL	24.4081 mL	61.0203 mL
Ethanol	5 mM	0.4882 mL	2.4408 mL	4.8816 mL	12.2041 mL
	10 mM	0.2441 mL	1.2204 mL	2.4408 mL	6.1020 mL
	15 mM	0.1627 mL	0.8136 mL	1.6272 mL	4.0680 mL
	20 mM	0.1220 mL	0.6102 mL	1.2204 mL	3.0510 mL
	25 mM	0.0976 mL	0.4882 mL	0.9763 mL	2.4408 mL
	30 mM	0.0814 mL	0.4068 mL	0.8136 mL	2.0340 mL
	40 mM	0.0610 mL	0.3051 mL	0.6102 mL	1.5255 mL