5α-Androstane-3β,5,6β-triol

Cat. No.: HY-100206 Purity: 99.74%: FAQs
Data Sheet SDS COA Handling Instructions

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5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo.

For research use only. We do not sell to patients.

5α-Androstane-3β,5,6β-triol Chemical Structure

CAS No. : 4725-51-3

Size	Price	Stock	Quantity
2 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Description

IC₅₀ & Target

AMPK^[1]

Molecular Weight

308.46

Formula

C₁₉H₃₂O₃

CAS No.

4725-51-3

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12CCC[C@@]1([H])[C@]3([H])C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (405.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2419 mL	16.2096 mL	32.4191 mL
5 mM	0.6484 mL	3.2419 mL	6.4838 mL
10 mM	0.3242 mL	1.6210 mL	3.2419 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.74%

Select Batch:

Data Sheet (247 KB) SDS (252 KB)

COA (253 KB) HNMR (267 KB) RP-HPLC (192 KB) MS (68 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2419 mL	16.2096 mL	32.4191 mL	81.0478 mL
	5 mM	0.6484 mL	3.2419 mL	6.4838 mL	16.2096 mL
	10 mM	0.3242 mL	1.6210 mL	3.2419 mL	8.1048 mL
	15 mM	0.2161 mL	1.0806 mL	2.1613 mL	5.4032 mL
	20 mM	0.1621 mL	0.8105 mL	1.6210 mL	4.0524 mL
	25 mM	0.1297 mL	0.6484 mL	1.2968 mL	3.2419 mL
	30 mM	0.1081 mL	0.5403 mL	1.0806 mL	2.7016 mL
	40 mM	0.0810 mL	0.4052 mL	0.8105 mL	2.0262 mL
	50 mM	0.0648 mL	0.3242 mL	0.6484 mL	1.6210 mL
	60 mM	0.0540 mL	0.2702 mL	0.5403 mL	1.3508 mL
	80 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0131 mL
	100 mM	0.0324 mL	0.1621 mL	0.3242 mL	0.8105 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5α-Androstane-3β,5,6β-triol4725-51-3Inhibitorinhibitorinhibit

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5α-Androstane-3β,5,6β-triol