2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Endogenous Metabolite
  4. 5-Methylcytosine-d4

5-Methylcytosine-d4 is the deuterium labeled 5-Methylcytosine[1]. 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine in mRNA is a new epitranscriptome marker inArabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development[2].

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5-Methylcytosine-d<sub>4</sub> Chemical Structure

5-Methylcytosine-d4 Chemical Structure

CAS No. : 1219795-15-9

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Methylcytosine-d4:

5-Methylcytosine-d4 Related Antibodies

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Description

5-Methylcytosine-d4 is the deuterium labeled 5-Methylcytosine[1]. 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine in mRNA is a new epitranscriptome marker inArabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Methylcytosine-d4 Related Antibodies
Molecular Weight

129.15

Formula

C5H3D4N3O
CAS No.
Unlabeled Cas

554-01-8
Appearance

Solid

Color

White to off-white

SMILES

NC1=C(C([2H])=NC(N1)=O)C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 7.14 mg/mL (55.28 mM; Need ultrasonic)

DMSO : 5 mg/mL (38.71 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.7429 mL 38.7147 mL 77.4294 mL
5 mM 1.5486 mL 7.7429 mL 15.4859 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 7.7429 mL 38.7147 mL 77.4293 mL 193.5734 mL
5 mM 1.5486 mL 7.7429 mL 15.4859 mL 38.7147 mL
10 mM 0.7743 mL 3.8715 mL 7.7429 mL 19.3573 mL
15 mM 0.5162 mL 2.5810 mL 5.1620 mL 12.9049 mL
20 mM 0.3871 mL 1.9357 mL 3.8715 mL 9.6787 mL
25 mM 0.3097 mL 1.5486 mL 3.0972 mL 7.7429 mL
30 mM 0.2581 mL 1.2905 mL 2.5810 mL 6.4524 mL
H2O 40 mM 0.1936 mL 0.9679 mL 1.9357 mL 4.8393 mL
50 mM 0.1549 mL 0.7743 mL 1.5486 mL 3.8715 mL
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5-Methylcytosine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Methylcytosine-d41219795-15-9DNA/RNA SynthesisEndogenous MetaboliteInhibitorinhibitorinhibit

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