4,6-Dioxoheptanoic acid-¹³C₅

Cat. No.: HY-W010184S: FAQs
Data Sheet SDS COA Handling Instructions

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4,6-Dioxoheptanoic acid-¹³C₅ is the ¹³C labeled 4,6-Dioxoheptanoic acid[1]. 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis[2].

For research use only. We do not sell to patients.

4,6-Dioxoheptanoic acid-<sup>13</sup>C<sub>5</sub> Chemical Structure

4,6-Dioxoheptanoic acid-¹³C₅ Chemical Structure

CAS No. : 881835-86-5

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1 mg	USD 420	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of 4,6-Dioxoheptanoic acid-¹³C₅:

4,6-Dioxoheptanoic acid In-stock

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Biological Activity
Purity & Documentation
References
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Description

4,6-Dioxoheptanoic acid-¹³C₅ is the ¹³C labeled 4,6-Dioxoheptanoic acid[1]. 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

163.12

Formula

C₂¹³C₅H₁₀O₄

CAS No.

881835-86-5

Unlabeled CAS

51568-18-4

Appearance

Solid

Color

White to off-white

SMILES

O=[13C]([13CH2][13C]([13CH3])=O)[13CH2]CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (613.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1305 mL	30.6523 mL	61.3046 mL
5 mM	1.2261 mL	6.1305 mL	12.2609 mL
10 mM	0.6130 mL	3.0652 mL	6.1305 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.7%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.1305 mL	30.6523 mL	61.3046 mL	153.2614 mL
	5 mM	1.2261 mL	6.1305 mL	12.2609 mL	30.6523 mL
	10 mM	0.6130 mL	3.0652 mL	6.1305 mL	15.3261 mL
	15 mM	0.4087 mL	2.0435 mL	4.0870 mL	10.2174 mL
	20 mM	0.3065 mL	1.5326 mL	3.0652 mL	7.6631 mL
	25 mM	0.2452 mL	1.2261 mL	2.4522 mL	6.1305 mL
	30 mM	0.2043 mL	1.0217 mL	2.0435 mL	5.1087 mL
	40 mM	0.1533 mL	0.7663 mL	1.5326 mL	3.8315 mL
	50 mM	0.1226 mL	0.6130 mL	1.2261 mL	3.0652 mL
	60 mM	0.1022 mL	0.5109 mL	1.0217 mL	2.5544 mL
	80 mM	0.0766 mL	0.3832 mL	0.7663 mL	1.9158 mL
	100 mM	0.0613 mL	0.3065 mL	0.6130 mL	1.5326 mL