2-Methoxyestrone-d₄

Name: 2-Methoxyestrone-d 4
Brand: MedChemExpress
SKU: HY-113252S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-113252S2 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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2-Methoxyestrone-d₄ is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81[1].

For research use only. We do not sell to patients.

2-Methoxyestrone-d<sub>4</sub> Chemical Structure

2-Methoxyestrone-d₄ Chemical Structure

CAS No. : 949885-90-9

Size	Price	Stock	Quantity
1 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Methoxyestrone-d₄:

2-Methoxyestrone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

2-Methoxyestrone-d₄ is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.42

Formula

C₁₉H₂₀D₄O₃

CAS No.

949885-90-9

Unlabeled Cas

362-08-3

Appearance

Solid

Color

White to yellow

SMILES

C[C@@]12[C@](CC([2H])([2H])C2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=C([2H])C(OC)=C(O)C([2H])=C4CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (164.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2849 mL	16.4247 mL	32.8493 mL
5 mM	0.6570 mL	3.2849 mL	6.5699 mL
10 mM	0.3285 mL	1.6425 mL	3.2849 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Lewis KM, et al. pKa values of estrone, 17 beta-estradiol and 2-methoxyestrone. Steroids. 1979 Nov;34(5):485-99. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2849 mL	16.4247 mL	32.8494 mL	82.1234 mL
	5 mM	0.6570 mL	3.2849 mL	6.5699 mL	16.4247 mL
	10 mM	0.3285 mL	1.6425 mL	3.2849 mL	8.2123 mL
	15 mM	0.2190 mL	1.0950 mL	2.1900 mL	5.4749 mL
	20 mM	0.1642 mL	0.8212 mL	1.6425 mL	4.1062 mL
	25 mM	0.1314 mL	0.6570 mL	1.3140 mL	3.2849 mL
	30 mM	0.1095 mL	0.5475 mL	1.0950 mL	2.7374 mL
	40 mM	0.0821 mL	0.4106 mL	0.8212 mL	2.0531 mL
	50 mM	0.0657 mL	0.3285 mL	0.6570 mL	1.6425 mL
	60 mM	0.0547 mL	0.2737 mL	0.5475 mL	1.3687 mL
	80 mM	0.0411 mL	0.2053 mL	0.4106 mL	1.0265 mL
	100 mM	0.0328 mL	0.1642 mL	0.3285 mL	0.8212 mL