2-Ketoglutaric acid-d₆

Name: 2-Ketoglutaric acid-d 6
Brand: MedChemExpress
SKU: HY-W013636S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-W013636S2 Purity: 98.62%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Ketoglutaric acid-d₆ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

For research use only. We do not sell to patients.

2-Ketoglutaric acid-d<sub>6</sub> Chemical Structure

2-Ketoglutaric acid-d₆ Chemical Structure

CAS No. : 1173021-86-7

Size	Price	Stock	Quantity
1 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 570	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Ketoglutaric acid-d₆:

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

152.14

Formula

C₅D₆O₅

CAS No.

1173021-86-7

Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

[2H]OC(C([2H])([2H])C([2H])([2H])C(C(O[2H])=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1643.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5729 mL	32.8645 mL	65.7289 mL
5 mM	1.3146 mL	6.5729 mL	13.1458 mL
10 mM	0.6573 mL	3.2864 mL	6.5729 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.62%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (249 KB) HNMR (142 KB) RP-HPLC (578 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief]

[3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5729 mL	32.8645 mL	65.7289 mL	164.3223 mL
	5 mM	1.3146 mL	6.5729 mL	13.1458 mL	32.8645 mL
	10 mM	0.6573 mL	3.2864 mL	6.5729 mL	16.4322 mL
	15 mM	0.4382 mL	2.1910 mL	4.3819 mL	10.9548 mL
	20 mM	0.3286 mL	1.6432 mL	3.2864 mL	8.2161 mL
	25 mM	0.2629 mL	1.3146 mL	2.6292 mL	6.5729 mL
	30 mM	0.2191 mL	1.0955 mL	2.1910 mL	5.4774 mL
	40 mM	0.1643 mL	0.8216 mL	1.6432 mL	4.1081 mL
	50 mM	0.1315 mL	0.6573 mL	1.3146 mL	3.2864 mL
	60 mM	0.1095 mL	0.5477 mL	1.0955 mL	2.7387 mL
	80 mM	0.0822 mL	0.4108 mL	0.8216 mL	2.0540 mL
	100 mM	0.0657 mL	0.3286 mL	0.6573 mL	1.6432 mL