N-(Phenylacetyl-d₅)glycine (Synonyms: 2-(2-Phenylacetamido)acetic acid-d₅)

Cat. No.: HY-W015061S: FAQs
Data Sheet SDS COA Handling Instructions

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N-(Phenylacetyl-d₅)glycine is the deuterium labeled Phenylacetylglycine. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion[1][2].

For research use only. We do not sell to patients.

N-(Phenylacetyl-d<sub>5</sub>)glycine Chemical Structure

N-(Phenylacetyl-d₅)glycine Chemical Structure

CAS No. : 1189920-31-7

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5 mg	USD 510	Ask For Quote & Lead Time

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Other Forms of N-(Phenylacetyl-d₅)glycine:

Phenylacetylglycine In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

198.23

Formula

C₁₀H₆D₅NO₃

CAS No.

1189920-31-7

Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 25 mg/mL (126.12 mM)

DMSO : ≥ 10 mg/mL (50.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 1 mg/mL (5.04 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0446 mL	25.2232 mL	50.4465 mL
5 mM	1.0089 mL	5.0446 mL	10.0893 mL
10 mM	0.5045 mL	2.5223 mL	5.0446 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Xu X, et al. The gut microbial metabolite phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion through activating β2AR. Arch Biochem Biophys. 2021 Jan 15;697:108720. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO / DMF	1 mM	5.0446 mL	25.2232 mL	50.4465 mL	126.1161 mL
Ethanol / DMSO / DMF	5 mM	1.0089 mL	5.0446 mL	10.0893 mL	25.2232 mL
DMSO / DMF	10 mM	0.5045 mL	2.5223 mL	5.0446 mL	12.6116 mL
	15 mM	0.3363 mL	1.6815 mL	3.3631 mL	8.4077 mL
	20 mM	0.2522 mL	1.2612 mL	2.5223 mL	6.3058 mL
	25 mM	0.2018 mL	1.0089 mL	2.0179 mL	5.0446 mL
	30 mM	0.1682 mL	0.8408 mL	1.6815 mL	4.2039 mL
	40 mM	0.1261 mL	0.6306 mL	1.2612 mL	3.1529 mL
	50 mM	0.1009 mL	0.5045 mL	1.0089 mL	2.5223 mL
DMF	60 mM	0.0841 mL	0.4204 mL	0.8408 mL	2.1019 mL
	80 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5765 mL
	100 mM	0.0504 mL	0.2522 mL	0.5045 mL	1.2612 mL

N-(Phenylacetyl-d₅)glycine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(Phenylacetyl-d₅)glycine1189920-31-72-(2-Phenylacetamido)acetic acid-d₅Adrenergic ReceptorApoptosisEndogenous MetaboliteBeta ReceptorInhibitorinhibitorinhibit

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N-(Phenylacetyl-d5)glycine (Synonyms: 2-(2-Phenylacetamido)acetic acid-d5)

Other Forms of N-(Phenylacetyl-d5)glycine:

N-(Phenylacetyl-d5)glycine Related Antibodies