2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR Endogenous Metabolite
  4. 15-Deoxy-Δ-12,14-prostaglandin J2-d4

15-Deoxy-Δ-12,14-prostaglandin J2-d4  (Synonyms: 15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4)

Cat. No.: HY-108568S Purity: 98.10%
COA Handling Instructions

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15-Deoxy-Δ-12,14-prostaglandin J2-d4 is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

For research use only. We do not sell to patients.

15-Deoxy-Δ-12,14-prostaglandin J2-d<sub>4</sub> Chemical Structure

15-Deoxy-Δ-12,14-prostaglandin J2-d4 Chemical Structure

CAS No. : 1542166-82-4

Size Price Stock Quantity
Solution
25 μg（312.05 μM * 250 μL in Methyl acetate） USD 260 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 15-Deoxy-Δ-12,14-prostaglandin J2-d4:

15-Deoxy-Δ-12,14-prostaglandin J2-d4 Related Antibodies

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Description

15-Deoxy-Δ-12,14-prostaglandin J2-d4 is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

15-Deoxy-Δ-12,14-prostaglandin J2-d4 Related Antibodies
Molecular Weight

320.46

Formula

C20H24D4O3
CAS No.
Unlabeled CAS

87893-55-8
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (156.03 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.10%

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1205 mL 15.6026 mL 31.2051 mL 78.0129 mL
5 mM 0.6241 mL 3.1205 mL 6.2410 mL 15.6026 mL
10 mM 0.3121 mL 1.5603 mL 3.1205 mL 7.8013 mL
15 mM 0.2080 mL 1.0402 mL 2.0803 mL 5.2009 mL
20 mM 0.1560 mL 0.7801 mL 1.5603 mL 3.9006 mL
25 mM 0.1248 mL 0.6241 mL 1.2482 mL 3.1205 mL
30 mM 0.1040 mL 0.5201 mL 1.0402 mL 2.6004 mL
40 mM 0.0780 mL 0.3901 mL 0.7801 mL 1.9503 mL
50 mM 0.0624 mL 0.3121 mL 0.6241 mL 1.5603 mL
60 mM 0.0520 mL 0.2600 mL 0.5201 mL 1.3002 mL
80 mM 0.0390 mL 0.1950 mL 0.3901 mL 0.9752 mL
100 mM 0.0312 mL 0.1560 mL 0.3121 mL 0.7801 mL
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15-Deoxy-Δ-12,14-prostaglandin J2-d4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-Deoxy-Δ-12,14-prostaglandin J2-d41542166-82-415d-PGJ2-d415-Deoxy-Δ12,14-PGJ2-d4PPAREndogenous MetabolitePeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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